NMDA antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514604, A61K 31405, A61K 3118

Patent

active

054708702

ABSTRACT:
The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.

REFERENCES:
patent: 3445479 (1969-05-01), Hydorn
patent: 4140697 (1979-02-01), Batcho et al.
The Journal of Neuroscience, Sep. 1990, 10(9):2965-297: Cerebral Synthesis and Release of Kynurenic Acid: an Endogenous Antagonist of Excitatory Amino Acid Receptors.
Society For Neuroscience Abstracts, vol. 17, 1991; 315.3; Systemic Loading with Kynurenine and Probenecid Markedly increases Striatal Kynurenic Acid Levels as Measured by In Vivo Microialysis, Miller, et al.
Chemical Abstracts 112(7): 52836c; Uptake of kynurenine into rat brain slices, Speciale, et al. (1990).
Chemical Abstracts 76(25): 150339a:Enzymic studies of the biosynthesis of 5-hydroxy-L-kynurenine in the rat small intestine, Konishi (1972).
Chemial Abstracts 75(3): 17141t; Pyrrole ring cleavaging enzyme of 5-hydroxytryptophan, Konishi, et al. (1971).
Chemical Abstracts 69(9):33829e; Formation of 5-hydroxy-L-kynurenine from L-kynurenine by hen liver microsomes; Kido, et al. 1968.
Chemical Abstracts 72(3)9673r; Influence of androgens on tryptophan metabolism in man, McGinty, et al. (1970).
Chemical Abstracts 74(21): 107987g; Gas, chromatographic analysis of tryptophan metabolites, Noguchi et al. (1971).
Chemical Abstracts 72(21): 107236v; 5-Hydroxykynurenine decarboxylase in rat intestine, Noguchi, et al (1970).
Chemical Abstracts 67(21):96860n; Metabolism of tryptophan, Griggio et al (1967).
Chemical Abstracts 111 (24):219114j; Sunscreens and skin-lightening cosmetics containing kynurenines; Narutomi, et al. (1989).
Chemical Abstracts 92 (5):36767u; The mechanism of Kynurenine hydrolysis catalyzed by kynureninase, Tanizawa, et al. (1980).
Chemical Abstracts 97(15):125986k; Halogenoanthranyloylalanines as sweeteners; Tanabe (1982).
Chemical Abstracts 93(25):239866u; An intensely sweet analog of kynurenine; Kawashima, et al. (1980).
Chemical Abstracts, 109:48451u (1988).
Chemical Abstracts, 106:207831z (1987).
Chemical Abstracts, 72:30438c (1970).
Chemical Abstracts, 83:131913m (1975).
Chemical Abstracts, 83:114922w (1975).
Chemical Abstracts, 96: 115515w (1982).
10-Microbia Biochem, vol. 112, 1990, Abstract No. 135860g.
Kynurenine metabolites of tryptophan: Implications for neurologic diseases; Freese, et al, 40, Neurology 691-695; Apr. 1990.
Chemical Abstracts 106: 78724r (1987).
Chemical Abstracts 95: 55548b (1981).

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