Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-02-05
1992-03-24
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548411, C07D20996, A61K 3140
Patent
active
050989251
ABSTRACT:
The present invention relates to spiroisoindolines that are antagonists at the phencyclidine receptor of the N-methyl-D-aspartate receptor complex and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides processes for preparing the spiroisoindolines, intermediates useful for their synthesis, pharmaceutical compositions containing them, and methods for their use.
REFERENCES:
patent: 3308134 (1967-03-01), Plostnieks
patent: 4240963 (1980-12-01), Laas et al.
Robinson et al., "A Novel Rearrangement Forming . . .", Tetrahedron Letters vol. 30, No. 39, pp. 5203-5206 (1989).
Brust Joseph Paul
Gabilan M. S. H.
ICI Americas Inc.
Jones James T.
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