Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-03-29
1992-03-24
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514183, 514212, 514424, 514425, 514426, 540451, 540463, 540482, 540485, 540526, 540527, 546203, 546204, 548528, 544380, A61H 31445, C07D21114
Patent
active
050989162
ABSTRACT:
Certain propanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula ##STR1## wherein each R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R.sup.3 and R.sup.4 may be taken together to form oxo;
REFERENCES:
patent: 3821249 (1974-06-01), Malen et al.
patent: 4758577 (1988-07-01), Young
A. F. Gilman et al., The Pharmacological Basis of Therapeutic 7th Edn., p. 403, MacMillan (1985).
S. M. Rothman et al., Annals of Neurology, 19(2), 105-111 (1986 ).
C. Carter et al., J. Pharm. Exp. Ther., 247(3), 1222-1232 (1988).
Cheng Brian K.
Gray Nancy M.
G. D. Searle & Co.
Ivy C. Warren
Keane J. Timothy
Matukaitis Paul D.
Turnipseed James H.
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