Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen

Details Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen

1989-11-06

1992-03-24

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 544357, 544398, 546236, A61K 31495, C07D29500

Patent

active

050989030

ABSTRACT:
Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes substituents comprising a hydroxy group, a hydrogen atom, an acetate group or a substituted or unsubstituted alkoxy group. The compounds are useful as antiestrogens and antitumor agents.

REFERENCES:
Hausser et al., "Solvolysis of Cyclopropyl Halides. III. 2,3-Diphenylcyclopropyl Chlorides", J. Org. Chem., 37: 4087-4090 (1972).
Magarian et al., "2-Chloro-1-phenylindene from 1,1-Dichloro-trans-2,3-diphenylcyclopropane", J. Pharmaceutical Sciences, 61: 1216-1219.
Magarian et al., "Synthesis of Cyclopropyl Analogs of Stilbene and Stilbenediol as Possible Antiestrogens", J. Pharm. Sci. 64: 1626-32.

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