Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-06-07
1991-03-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
560 1, 560 11, 560 12, 560 13, 560 17, 560 20, 560 22, 560 23, 560 27, 560 29, 560 31, 560 32, 560 47, 560 49, 560 64, 560 65, 560 73, 560105, 560107, 560121, 560123, 560125, 560127, 560148, 560159, 560160, 560161, 560162, 560124, 514333, 514336, 514341, 514342, 514343, 514354, 514355, 514356, 514438, 514448, 514444, 514269, 514274, 514256, 514369, 514365, 514258, 514300, 514301, 514302, 514247, 514406, 514407, 514225, 514460, 514510, 514824, 5142275, 5142278, 5142318, 5142322, 5142372, 5142358, 5142375, 5
Patent
active
050011480
ABSTRACT:
Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from:
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F. M. Singer et al., "New Inhibitors of in vitro Conversion of Acetate and Mevalonate to Cholesterol", Proc. Soc. Exper. Biol. Med., 102, 370 (1959).
F. H. Hulcher, "Inhibition of Hepatic Cholesterol Biosynthesis by 3,5-Dihydroxy-3,4,4-Trimethylvaleric Acid and its Site of Action", Arch. Biochem. Biophys., 146, 422 (1971).
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Gordon Eric M.
Saunders Jeffrey O.
Barrack Donald J.
E. R. Squibb & Sons Inc.
Gaul Timothy J.
Raymond Richard L.
Russell M. L.
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