Substituted cyclohexene derivatives as HMG-CoA reductase inhibit

Details Substituted cyclohexene derivatives as HMG-CoA reductase inhibit Substituted cyclohexene derivatives as HMG-CoA reductase inhibit

1990-04-17

1991-03-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 11, 549 22, 549 39, 549264, 549333, 549341, 549342, 514431, 514440, 514450, 514452, 514462, 514824, A61K 31385, C07D33908

Patent

active

050011448

ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Phamaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

REFERENCES:
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patent: 4308378 (1981-12-01), Stokker
patent: 4503072 (1985-03-01), Hoffman et al.
patent: 4567289 (1986-01-01), Willord et al.
patent: 4611067 (1986-09-01), Volante et al.
patent: 4622338 (1986-11-01), Baran et al.
patent: 4668699 (1987-05-01), Hoffman et al.
patent: 4681893 (1987-07-01), Roth
patent: 4772626 (1988-09-01), Smith et al.

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