Process for preparation of bicyclic compounds

Details Process for preparation of bicyclic compounds Process for preparation of bicyclic compounds

1989-01-30

1992-03-24

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

548452, A61K 3700

Patent

active

050988921

ABSTRACT:
New bicyclic compounds, inclusive of salts thereof, of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, hydroxyl or lower alkoxy, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen, lower alkyl, amino-lower-alkyl or acylamino-lower-alkyl, R.sup.5 is hydrogen, lower alkyl or aralkyl which may be substituted, R.sup.6 is hydroxyl, lower alkoxy, amino or lower alkylamino, and m and n each means 1 or 2, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

REFERENCES:
patent: 4374829 (1983-02-01), Harris et al.
patent: 4587258 (1986-05-01), Gold et al.
Zeolite Chemistry and Catalysts Rabo, p. 582 (1976).

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