Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hyd

Details Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hyd Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hyd

1990-06-07

1991-03-19

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514349, 546297, 546283, 546284, A61K 3144, C07D21374, C07D40512

Patent

active

050011367

ABSTRACT:
2-substitutedmethylamino-amino 5-(hydroxy or alkoxy) pyridines and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, dermatological, allergic and cardiovascular diseases.

REFERENCES:
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Chang et al., Biochemistry 26(2), 360-367 (1987).
Crank et al., J. Heterocycl. Chem. 22(5), 1281-1284 (1985).

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