Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-12-15
1991-03-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 15, 548407, 549 13, 549264, 549330, 560 39, 560 59, 562444, 562448, 562469, 514409, 514432, 514462, 514530, 514531, 514538, 514540, 514559, 514567, 514569, 514570, 514824, A61K 3144, C07D21324, C07D20910
Patent
active
050011286
ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids and esters derived therefrom and pharmaceutically acceptable salts thereof.
Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.
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Neuenschwander Kent W.
Scotese Anthony C.
Balogh Imre (Jim)
Nicholson James A.
Raymond Richard L.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Russell Mark W.
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