Process for producing N-acyl-D,L-phenylalanine ester

Details Process for producing N-acyl-D,L-phenylalanine ester Process for producing N-acyl-D,L-phenylalanine ester

1982-03-11

1983-11-08

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548228, C07C10108

Patent

active

044144040

ABSTRACT:
A process for preparing a racemic mixture of N-acyl-D,L-phenylalanine ester by reacting the azlactone of N-acyl-acetaminocinnamic acid with hydrogen at a hydrogen pressure of at least about 100 psig at a temperature within the approximate range of about 50.degree.-200.degree. C. in the presence of a nickel hydrogenation catalyst, a lower alkanol and an alkali metal or an alkaline earth metal alkoxide.

REFERENCES:
patent: 3963573 (1976-06-01), Stauffer
patent: 4262092 (1981-04-01), Bauer
Kaneko et al, Synthetic Production and Utilization of Amine Acids, (1974), 171-179.
Bacillus subtilis, Guntelberg Trav. Lab. Carlsberg, Ser. Chim., vol. 29, (1954), 36-48.
Barel, Jour. Biological Chemistry, vol. 23, No. 7, (1968), 1344-1348.
Badshah et al., Jour. Organic Chemistry, vol. 37, No. 18, (1972), 2916-2918.
Knowles et al, Homogeneous Catalysis, vol. 2, 274-282.

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