Process for the production of tetronic acid

Details Process for the production of tetronic acid Process for the production of tetronic acid

1982-06-14

1983-11-08

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560174, C07D30760

Patent

active

044144008

ABSTRACT:
Process for the production of tetronic acid from 4-haloacetoacetic ester. The 4-haloacetoacetic ester is transformed into the corresponding 4-tertiary-butoxyacetoacetic ester and the latter is converted by cyclizing ether cleavage into tetronic acid. Preferably the cyclizing ether cleavage is carried out thermolytically at a temperature above 100.degree. C. or is carried out by treatment with an acid at a temperature of 0.degree. to 30.degree. C. Tertiary-butoxyacetoacetic acid ethyl ester is a new compound.

REFERENCES:
patent: Re28242 (1974-11-01), Boosen
patent: 3824255 (1974-07-01), Boosen
Baan et al., "The Total Synthesis of the Antibiotic Malonomicin," Tetrahedron, vol. 34, (1978), pp. 223 to 231.

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