Process for the manufacture of hydrazono-isoindolines

Details Process for the manufacture of hydrazono-isoindolines Process for the manufacture of hydrazono-isoindolines

1981-03-06

1983-11-08

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564250, 546107, C07D20944

Patent

active

044143958

ABSTRACT:
The invention relates to a process for the manufacture of 1-hydrazono-isoindolines of the formula ##STR1## wherein Y is a methine or imine radical and the ring A can contain substituents which do not confer solubility in water, by reacting an iminoisoindoline of the formula ##STR2## with hydrazine or a hydrazine donor, in a polar solvent, which process comprises carrying out the reaction at temperatures below 80.degree. C.
These hydrazono-isoindolines are obtained in excellent yield and purity and can be used without further purification as starting materials for further syntheses.

REFERENCES:
patent: 2973358 (1961-02-01), Pugin
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patent: 3646033 (1972-02-01), Leister et al.
patent: 4022770 (1977-05-01), L'Eplattenier et al.
patent: 4132708 (1979-01-01), L'Eplattenier et al.
patent: 4139563 (1979-02-01), Metcalf et al.
patent: 4237292 (1980-12-01), L'Eplattnier et al.
Thielhiemer, W.; Synthetic Methods of Organic Chemistry, vol. 21, No. 53.

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