Process for preparing 4-(substituted phenyl)-3,4-dihydro-2H-naph

Details Process for preparing 4-(substituted phenyl)-3,4-dihydro-2H-naph Process for preparing 4-(substituted phenyl)-3,4-dihydro-2H-naph

1999-03-01

2000-08-15

Padmanabhan, Sreeni

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568319, 568323, C07C 4545

Patent

active

061039381

ABSTRACT:
4-(Substituted phenyl)-3,4-dihydro-2H-naphthalen-1-ones, which are useful as intermediates in the preparation of antidepressant agents, are conveniently prepared by reacting 1-substituted naphthalenes and an aromatic moiety in the presence of an acid catalyst. 4-(3,4-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one, which is useful as an intermediate in the preparation of the antidepressant sertraline, is conveniently prepared by reacting 1-naphthyl acetate and o-dichlorobenzene in the presence of an acid catalyst.

REFERENCES:
patent: 4839104 (1989-06-01), Quallich et al.
patent: 5019655 (1991-05-01), Adrian
patent: 5196607 (1993-03-01), Quallich
patent: 5466880 (1995-11-01), Quallich

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