Catalyst that oxidizes steroids and other substrates with cataly

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536103, 536124, C07H 100, C07H 300, C07H 1302

Patent

active

06103892&

ABSTRACT:
The present invention provides a metalloporphyrin catalyst represented by the structure: ##STR1##

REFERENCES:
Ellis et al. Coord. Chem. Rev. 105, 181-193, 1990.
Breslow et al. J. Am. Chem. Soc. 118: 11678-11679, 1996.
Breslow, R. "Biomimetic Control of Chemical Selectivity." Acc. Chem. Res. (1980) vol. 13, 170-177.
Breslow, R. "Biomimetic Chemistry and Artificial Enzymes: Catalysis by Design." Acc. Chem. Res. (1995)vol. 28, 146-153.
Breslow, R., Brown, A. B., McCullough, R. D. & White, P. W. "Substrate Selectivity in Epoxidation by Metalloporphyrin and Metallosalen Catalysts Carrying Binding Groups." J. Am. Chem. Soc. (1989) vol. 111, 4517-4518.
Breslow, R.; Gabriele, B.; Yang, J. "Geometrically Directed Selective Steroid Hydroxylation with High Turnover by a Fluorinated Artificial Cytochrome P-450." Tetrahedron Lett. (1998) vol. 39, 2887-2890.
Breslow, R.; Huang, Y.; Zhang, X.; Yang, J. "An artificial cytochrome P450 that hydroxylates unactivated carbons with regio- and stereoselectivity and useful catalytic turnovers." Proc. Natl. Acad. Sci. USA (1997)vol. 94,11156-11158.
Breslow, R.; Zhang, X.; Huang, Y. "Selective Catalytic Hydroxylation of a Steroid by an Artificial Cytochrome P-450 Enzyme." J. Am. Chem. Soc. (1997) vol. 119,4535-4536.
Breslow, R.; Zhang, X.; Xu, R.; Maletic, M.; Merger, R. "Selective Catalytic Oxidation of Substrates That Bind to Metalloporphyrin Enzyme Mimics Carrying Two or Four Cyclodextrin Groups and Related Matallosalens." J. Am. Chem. Soc. (1996) vol. 118, 11678-11679 (Exhibit 7).
Ellis, P. E.; Lyons, J. E. "Selective Air Oxidation of Light Alkanes by Activated Metalloporphyrins-The Search for a Suprabiotic System." Coord. Chem. Rev. (1990), vol. 105, 181-193.
Fujita, K.; Ueda, R.; Imoto, T.; Tabushi, I.; Toh, N.; Koga, T. "Guest-Induced Conformational Change of .beta.-Cyclodextrin Capped with an Environmentally Sensitive Chromophore." Bioorg. Chem. (1982), vol. 11, 72-84.
Grieco, P. A. & Stuk, T. L. "Remote Oxidation of Unactivated C-H Bonds in Steroids via Oxometalloporphinates." J. Am. Chem. Soc. (1990) vol. 112, 7799-7801.
Groves, J. T. & Neumann, R. "Regioselective Oxidation Catalysis in Synthetic Phospholipid Vesicles. Membrane-Spanning Steroidal Metalloporphyrins." J. Am. Chem. Soc. (1989) vol. 111, 2900-2909 (Exhibit 11).
Groves, J. T. & Neumann, R. "Membrane-Spanning Metalloporphyrins as Site-Selective Catalysts in Synthetic Vesicles." J. Am. Chem. Soc. (1987) vol. 109, 5045-5047.
Groves, J. T. & Neumann, R. "Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin." J. Org. Chem. (1988) vol. 53, 3891-3893.
Kaufman, M. D., Grieco, P. A. & Bougie, D. W. "Functionalization of Unactivated C-H Bonds in Steroids via (Salen) manganese (III) Complexes." J. Am. Chem. Soc. (1993) vol. 115, 11648-11649.
Stuk, T. L., Grieco, P. A. & Marsh, M. M. "Site-Selective Hydroxylation of Steroids via Oxometalloporphinates Covalently Linked to Ring D: Introduction of Hydroxyl Groups into the C(9) and C(12) Position of 5.alpha.-Androstanes." J. Org. Chem. (1991) vol 56, 2957-2959.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Catalyst that oxidizes steroids and other substrates with cataly does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Catalyst that oxidizes steroids and other substrates with cataly, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Catalyst that oxidizes steroids and other substrates with cataly will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2008357

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.