Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-10-14
2000-08-15
Budens, Robert D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4241331, 4241361, 5303873, C07H 2102, C07H 2104
Patent
active
06103889&
ABSTRACT:
Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
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Bird Robert E.
Filpula David
Hardman Karl D.
Whitlow Marc D.
Budens Robert D.
Enzon Inc.
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