Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-06-01
2000-08-15
Housel, James C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 44, C07H 2104
Patent
active
061038881
ABSTRACT:
Compositions and methods for the treatment and diagnosis of lipopolysaccharide-related conditions and coagulant-related disease are provided. Compositions include polypeptides which are identical or homologous to a certain cationic protein (CAP18) obtained from mammalian granulocytes, particularly including a reactive nitrogen inhibiting peptide (RNIP) fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated activation of macrophage, as well as interfering with the clotting cascade to inhibit coagulation in conditions such as disseminated intravascular coagulation. Compositions comprising the polypeptides in a suitable pharmaceutical carrier are also provided.
REFERENCES:
patent: 4134792 (1979-01-01), Boguslaski et al.
patent: 5618675 (1997-04-01), Larrick et al.
patent: 5627262 (1997-05-01), Pereira
patent: 5643570 (1997-07-01), Theofan et al.
patent: 5650392 (1997-07-01), Pereira et al.
Hirata, N. et al. "Agglutination of Erythrocytes Sensitized with Re-LPS Elicited by Cationic Protein from Rabbit Granulocytes," Endotoxin: Structural Aspects and Immunobiology of Host Responses; Meeting Abstract, Riva del Sole, Giovinazzo (BARI), Italy (May 29-Jun. 1, 1986).
Tsunoda, N. et al. "Anticoagulant, Antiendotoxin and Anti-Bacterial Activities of Cationic Proteins," International Conference on Endotoxins Amsterdam II; Abstract, Academic Medical Centre, Amsterdam, The Netherlands (May 22-23, 1987).
Yoshida, M. et al. "Investigations of Endotoxin Binding Cationic Proteins from Granulocytes as Natural Defense Systems," International Symposium on Endotoxin; Abstract, JICHI Medical School, Japan (May 11-13, 1988).
Shimomura, Y. et al. "Anticoagulant and Antibacterial Activities of Endotoxin-Binding Cationic Protein from Rabbit Granulocytes," XIIth Congr. of the Intl. Society on Thrombosis and Haemostasis; Abstract, Tokyo, Japan (Aug. 19-25, 1989).
Hirata, M. et al. "Interaction of LPS with Cationic Protein From Granaulocytes," IUMS Congress: Bacteriology & Mycology; Abstract, Osaka, Japan (Sep. 16-22, 1990).
Hirata, M. et al. "Modification of LPS Activity by LPS-Binding Progein (cap-18)," The First Congress of the International Endotoxin Society; Abstract, San Diego, CA (May 10-12, 1990).
Hirata, M. et al. "Investigation of Endotoxin Binding Cationic Proteins From Granulocytes; Agglutination of Erythrocytes Sensitized with RE-LPS," Advances in Experimental Medicine and Biology, vol. 256, pp. 287-299 (1990).
Larrick, J.W. et al. "Complementary DNA Sequence of Rabbit CAP-18--A Unique Lipopolysaccharide Binding Protein," Biochemical and Biophysical Research Communications, vol. 179, No. 1, (Aug. 30, 1991).
Hirata, M. et al., "Bacterial Endotoxins," Fourth Int'l Conference on Endotoxins, Amsterdam, Netherlands, pp. 147-159 (Aug. 1993).
Pungercar, J. et al., FEBS Letters, vol. 336, No. 2, pp. 284-188 (Dec. 1993).
Saba et al. Blood 31:369-380 (1968).
Saba et al., "Anti-Heparin Activity of Lysomal Cationic Proteins from . . . " Blood, vol. 31, No. 3, p. 369 (1968).
Harlow, E. et al. "Antibodies: A Laboratory Manual", pp. 55-136 (1988).
Jawetz, E. et al., Review of Medical Microbiology, 11.sup.th Edition, p. 208, Chapter 18.
Hirata Michimasa
Larrick James W.
Wright Susan C.
Housel James C.
Panorama Research, Inc.
Portner Ginny Allen
LandOfFree
Mammalian cationic proteins having lipopolysaccharide binding an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mammalian cationic proteins having lipopolysaccharide binding an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mammalian cationic proteins having lipopolysaccharide binding an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2008328