N-Acyl derivatives of 6-alkylamino 5-chloro-3-nitropyrazinamines

Details N-Acyl derivatives of 6-alkylamino 5-chloro-3-nitropyrazinamines N-Acyl derivatives of 6-alkylamino 5-chloro-3-nitropyrazinamines

1982-07-19

1983-11-08

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544120, 544359, 544409, 4142484, A61K 31495, C07D24116, C07D24120

Patent

active

044142153

ABSTRACT:
N-Acyl derivatives of 6-(alkylamino)-5-chloro-3-nitro-pyrazinamines are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 3541093 (1970-11-01), Tull et al.
patent: 3660397 (1972-02-01), Jones et al.
Ainsworth, et al., Canadian J. Biochemistry, vol. 56 (1978), pp. 457-461.
Adams, et al., The Lancet (Jan. 1976), pp. 186-188.
Olive, Peggy, Cancer Research, vol. 39, (Nov. 1979), pp. 4512-4515.
Anderson, et al. British J. of Cancer, vol. 37, (1978), pp. 103-106.

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