Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1999-02-12
2000-08-15
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435375, C12N 1563, C12N 510
Patent
active
061035319
ABSTRACT:
A method for reducing levels of JAK 1 and thereby blocking the signal transduction pathways that are employed by IFN-.alpha., IFN-.beta., and IFN-.gamma. is provided. In one embodiment the method comprises the steps of: providing a cytomegalovirus (CMV) gene product selected from the group consisting of the CMV immediate early gene (IE) products, the CMV early gene (E) products, and combinations thereof; and introducing the CMV gene product or products into cells at levels sufficient to decrease the levels of JAK 1 in the cell. In another embodiment the method comprises the steps of providing a DNA molecule that comprises a CMV IE gene, a CMV E gene, or combinations thereof; introducing the DNA molecule into the cell; and inducing the expression of CMV IE and E genes in the cell, wherein the expression of products encoded by the CMV IE and CMV E genes decreases the levels of JAK 1 in the cell.
REFERENCES:
Sedmak et al., Am. J. Pathol. 144: 683-692, 1994, Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.
Gompels et al., Virology 209: 29-51, 1995, The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.
"Viral effects on antigen processing" by Miller, et al., Current Opinion in Immunology, Feb. 1999, 11:94-99.
"Human Cytomegalovirus Inhibits IFN-.alpha.-stimulated Antiviral and Immunoregulatory Responses by Blocking Multiple Levels of IFN-.alpha. Signal Transduction" by Miller, et al. The Journal of Immunology, May 15, 1999, 162:6107-6113.
"Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression by Disruption of the Jak/Stat Pathway" by Miller, et al., J. Exp. Med., vol. 187, No. 5, Mar. 2, 1998, pp. 675-683.
Miller Daniel
Rahill Brian
Sedmak Daniel
Zhang Yingxue
Ohio State Research Foundation
Ousley Andrea
Schwartzman Robert A.
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