Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-02-11
2000-08-15
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435373, 435 6, G01N 33567, G01N 3353, C12Q 168
Patent
active
061034827
ABSTRACT:
Methods for determining the sensitizing, irritant and/or allergenic potential of a candidate substrate are provided. These methods involve simultaneously cultivating keratinocytes and Langerhans cell precursors in a nutrient medium in order to effect differentiation of the Langerhans cell precursors, and contacting the candidate substrate with the cultured cells to determine the effect if any on markers associated with sensitizing, irritant or allergenic potential.
REFERENCES:
A. Rambukkana et al. "Effects of contact allergens on human Langerhans cells . . . "; Laboratory Investigation, vol. 74, No. 2, 1996, Washington, D.C., pp. 422-436, XP002043544.
F.H.M. Pistoor et al, "Novel predictive assay for contact allergens . . . ", American Journal of Pathology, vol. 149, No. 1, Jul. 1, 1996, Washington, D. C., pp. 337-343, XP002043821.
Muller, G., et al. Human keratinocyte-derived IL-12 affects LC-induced allogeneic T-cell responses. Advances in Experimental Medicine and Biology, 378:519-521, 1995.
Tsuchida, T., et al. Epidermal Langerhans cells can function as stimulatory cells but not as accessory cells in CTL induction. J. Immunol. 132:1163-1168, Mar. 1984.
Schuler, G., et al. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161:526-546, Mar. 1985.
Reid, C.D., et al. Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+progenitors in human bone marrow. J. Immunol, Oct. 1992.
Roitt, I.M. and Delves, P.J. Editors. Encyclopedia of Immunology. Academic Press, London, p. 640, 1993.
Shimada, S., et al. Enhanced antigen-presenting capacity of cultured Langerhans cells is associated with markedly increased expression of la antigen. J. Immunol. 139:2551-2555, Oct. 1987.
Regnier Marcelle
Schmidt Rainer
Chan Christina Y.
Pelley Ronald
Societe l'Oreal S.A.
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