Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548517, 549 58, 514253, 549 60, 514307, 549396, 549462, 514309, 549471, 514312, 514314, 514337, 514359, 514361, 514365, 514367, 514382, 514383, 514414, 514422, 514443, 514444, 514470, 544405, 546149, 546152, 546269, 548126, 548127, 548128, 548134, 548136, 548159, 548203, 548252, 548256, 548262, 548509, A61K 3134, A61K 3135, C07D30779, C07D31158

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045379033

ABSTRACT:
Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

REFERENCES:
patent: 3865748 (1975-02-01), Jurd et al.
patent: 4105698 (1978-08-01), Starks
Hurd et al., J.A.C.S., vol. 59, pp. 107-109, (1937).
Barnes et al., Tetrahedron, vol. 21, pp. 2707-2715, (1965).
K. H. Baggaley et al., J. Chem. Soc., D1970, (1), 6-7.

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