Spiro-tricyclicaromatic succinimide derivatives as inhibitors of

Details Spiro-tricyclicaromatic succinimide derivatives as inhibitors of Spiro-tricyclicaromatic succinimide derivatives as inhibitors of

1983-09-14

1985-08-27

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514248, 514250, 514366, 514387, 514409, 544230, 546 16, 546 17, 546 18, 548126, 548147, 548301, 548302, 548411, A61K 31415, C07D48710, C07D48720

Patent

active

045378924

ABSTRACT:
Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.

REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4117230 (1978-09-01), Sarges
patent: 4130714 (1978-12-01), Sarges
patent: 4209630 (1980-06-01), Sarges
Chemical Abstracts 87: 184427(y), (1977), [Trigo, G. et al., An. Quim, (1977), 73(2), 282-4].
Chemical Abstracts, 91: 56913w, (1979), [Trigo, G., et al., An. Quim, (1978), 74(7-8), 1090-1092].
Pan, Hsi-Lung, et al., "Derivatives of Fluorene, XVIII, New Halogenofluorenes, I, Potential Antitumor Agents," J. Med. Chem., vol. 7, 1964, pp. 31-38.
Pan, Hsi-Lung, et al., "Derivatives of Fluorene, XXIV, Synthesis and Antitumor Activities of Some Imidazolidine-2,5-diones," J. Med. Chem., vol. 10, 1967, pp. 957-959.
Winstead, Meldrum B., et al., "Relationship of Molecular Structure to in Vivo Scintigraphic Distribution Patterns . . . ," J. Med. Chem., vol. 19, 1976, pp. 279-286.

Affiliated with

Also associated with

Rating

Spiro-tricyclicaromatic succinimide derivatives as inhibitors of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spiro-tricyclicaromatic succinimide derivatives as inhibitors of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiro-tricyclicaromatic succinimide derivatives as inhibitors of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2001862