Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1981-11-12
1985-08-27
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351722, 435240, 435241, 435948, 424 94, 935 99, 935109, 935 34, C12N 972, C12N 1500, C12N 500, C12R 191
Patent
active
045378525
ABSTRACT:
The present invention relates to a process for the production of human urokinase. More precisely, the present invention relates to a process for the mass production of human urokinase, comprising in vivo multiplication of human cells capable of producing human urokinase, using the nutrient body fluid of a non-human warm-blooded animal, and exposure of the multiplied human cells to an urokinase inducer. The human urokinase present production according to the invention is much higher than that attained by conventional methods; thus, human urokinase can be used in sufficient amount in the prevention and treatment of human diseases.
REFERENCES:
patent: 4195125 (1980-03-01), Wacker
patent: 4232124 (1980-11-01), Mann
patent: 4242460 (1980-12-01), Chick et al.
patent: 4276282 (1981-06-01), Sugimoto
patent: 4285929 (1981-08-01), Sugimoto
patent: 4328207 (1982-05-01), Sugimoto
patent: 4328314 (1982-05-01), Horiguchi et al.
patent: 4352883 (1982-10-01), Lim
patent: 4377513 (1983-03-01), Sugimoto
patent: 4383034 (1983-05-01), Sugimoto
patent: 4383035 (1983-05-01), Sugimoto
patent: 4383036 (1983-05-01), Sugimoto
Zeleznik et al., "Production of Long Term Steroid-Producing Granulosa Cell Cultures by Cell Hybridization", Endocrinology 105(1), (1979), pp. 156-162.
Bordelon et al., "Human Glycoprotein Horomone Production in Human-Human Somatic Cell Hybrids", Experimental Cell Research 103(2), (1976), pp. 303-310, Chem. Abst. 86: 53094r.
Markus et al., "Content and Characterization of Plasminogen Activators in Human Lung Tumors and Normal Lung Tissue", Cancer Research 40(3), (1980), pp. 841-848, Chem. Abst. 92: 144676x.
Wilsonet et al., "Molecular Species of Plasminogen Activators Secreted by Normal and Neoplastic Human Cells", Cancer Research 40(3), (1980), pp. 933-938, Chemical Abstracts 92: 144679a.
Bernik et al., "Production by Human Tissues in Culture of Immunologically Distinct, Multiple Molecular Weight Forms of Plasminogen . . . ", Ann. N.Y. Academy of Sciences, 370, (1981), pp. 592-608, Chem Abst. 95: 94388u.
Shin, "Use of Nude Mice for Tumorigenicity Testing and Mass Propagation", Methods in Enzymology, vol. LVIII, pp. 370-379.
Kennett, "Cell Fusion", Methods in Enzymology, vol. LVIII, (1979), pp. 345-351.
Allan et al., "Co-Expression of Differentiation Markers in Hybrids Between Friend Cells and Lymphoid Cells and the Influence of . . . ", Cell, vol. 19, (1980), pp. 437-447.
Deisseroth et al., "Hemoglobin Synthesis in Somatic Cell Hybrids: & Globin Gene Expression in Hybrids Between Mouse . . . ", Proceedings of the National Academy of Sciences, 72(3), 1975), pp. 1102-1106.
Lewis, "Plasminogen Acticator (Urokinase) from Cultured Cells", Thromb. Haemostasis 42(3), (1979), pp. 895-900, Chem. Abst. 92: 55678g.
Udris, et al., "Diagnosis of the Gravity of Acute Leukemia", U.S.S.R. Pat. No. 648,206, Chemical Abstracts 90:166249.
Rothblat et al., "Growth, Nutrition, and Metabolism of Cells in Culture", vol. II, Academic Press, NY 1978, pp. 224-243.
Knazek, "Solid Tissue Masses Formed in Vitro from Cells Cultured on Artificial Capillaries", Federation Proceedings 33(8), pp. 1978-1981, (1974).
Goding, "Antibody Production by Hybridomas", Journal of Immunological Methods, 39, pp. 285-308, (1980).
Ponten, J., et al., "Morphological and Virological Investigation of Human Tissue Cultures Transformed with SV.sub.40 ", J. of Cellular and Comparative Physiology, vol. 61, 145-154, (1963).
Pattillo, "Hormone Synthesis and Function in vitro", Growth, Nutrition and Metabolism of Cells in Culture, 1972, Academic Press, N.Y., 225-227.
Lewin, Gene Expression, Wiley & Sons, pp. 259-265, 1980.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Tarcza John E.
Wiseman Thomas G.
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