Penetrating topical pharmaceutical compositions containing N-(2-

Details Penetrating topical pharmaceutical compositions containing N-(2- Penetrating topical pharmaceutical compositions containing N-(2-

1983-06-21

1985-08-27

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514171, 514549, 514300, 514826, 514825, 514859, A01N 4336, A61K 3140

Patent

active

045377766

ABSTRACT:
Topical pharmaceutical compositions comprising a pharmaceutically-active agent and a novel, penetration-enhancing vehicle or carrier are disclosed. The vehicle or carrier comprises a binary combination of N-(2-Hydroxyethyl) pyrrolidone and a "cell-envelope disordering compound". The compositions provide marked transepidermal and percutaneous delivery of the active selected. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

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