Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophen

Details Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophen Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophen

1977-10-28

1980-03-11

Waltz, Thomas A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26032682, 260556B, 260571, 260577, 544 59, 544158, 544383, 546192, 546334, 4242485, 42424852, 424250, 424267, 424274, 424321, 424330, 424263, A61K 31135, A61K 3144, C07C 8750, C07C 8760

Patent

active

041928733

ABSTRACT:
The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower alkyl, R.sub.1 is hydrogen or lower alkyl, R.sub.2 is lower alkyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or substituted or unsubstituted pyridyl, R.sub.3 is hydrogen or lower alkyl and n is 1 or 2, with the exception of 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone, 2'-amino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-chloro-2-(methylsulphinyl)-acetophenone, 2'-methylamino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-methyl-2-(methylsulphinyl)-acetophenone, 2'-amino-4'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-6'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-5',6'-dimethoxy-2-(methylsulphinyl)-acetophenone and 2'-amino-4',5'-dimethoxy-2-(methylsulphinyl)-acetophenone, and also to their salts.
These compounds have a fibrinolytic and an antiinflammatory action.

REFERENCES:
patent: 2797218 (1957-06-01), Barber et al.
patent: 3355494 (1967-11-01), Lyness et al.
patent: 3409674 (1968-11-01), Moore
patent: 3637803 (1972-01-01), Shen et al.
patent: 3937704 (1976-02-01), Strandtmann et al.
Leonard, N. J., "The Chemistry of Cinnolenes", Chim Rev. 37, only pp. 269, 270, 271 & 272 relied upon.

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