Non-specific suppressive factors and process

Details Non-specific suppressive factors and process Non-specific suppressive factors and process

1983-09-19

1985-08-27

Kight, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424101, 514 2, C07G 700

Patent

active

045377120

ABSTRACT:
A high purity immunosuppression factor (IF) having a molecular weight of about 50,000 or a reduced IF having a molecular weight of about 25,000 derived from the higher molecular weight IF and which is stable in dilute aqueous solutions is obtained from human ascites fluid. An extract of human ascites fluid is subjected to chromatography to recover a component of the ascites fluid rich in the immunosuppression factor and containing proteinaceous material which does not degrade the IF factor. The pure IF is obtained by subjecting the component rich in IF to contact with solid phase anti-human IgG (Fc specific) to recover pure IF having a molecular weight of above 50,000. The reduced IF is obtained by heating the higher molecular weight IF.

REFERENCES:
Oh et al., Fed. Proc. 39 (3) Abstract #4719, 1980.
Nelken et al., J. Immunological Methods, vol. 28, pp. 267-276, 1979.

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