Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1996-02-08
1998-07-28
Beisner, William H.
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204601, G01N 2726, G01N 27447
Patent
active
057858314
ABSTRACT:
A method and apparatus for mixing liquids using electroosmotic flow. Multiple capillaries (100, 104, 106) or microchip channels meet at a common junction (102). One capillary (100) is used for mixed liquids and each of the remaining capillaries (104, 106) are used for supplying a liquid (112, 114) to be mixed. Each of the supply capillaries (104, 106) has a free end that is immersed into a vial (108, 110) of liquid (112, 114). A first power supply terminal (112) is attached to a free end of the mixed liquid capillary (100). The liquid in each vial has an electrode that is switchably connected to a second power supply terminal. Closing a switch (116, 118) causes liquid to flow from a vial through the common junction and through the mixed liquid capillary. Each switch is independent and each may be closed continuously, switched at a constant duty cycle, or switched at a variable duty cycle. As a result, continuous mixing or variable ratio mixing may be achieved.
REFERENCES:
Kurt Seller et al, "Electroosmotic Pumping and Valveless Control of Fluid Flow within a Manifold of Capillaries on a Glass Chip" Analyical Chemistry, vol. 66, No. 20 (15 Oct. 1994) 3485-3491.
Stephen C. Jacobson et al "Microchip Capillary Electrophoresis with an Integrated Postcolumn Reactor" Analytical Chemistry, vol 66, No. 20 (15 Oct. 1994) 3472-3476.
European Search Report for Application No. 95102304.3 dated 11 Aug. 1995.
Analytical Chemistry, vol. 66, No. 20, 15 Oct. 1994 Columbus US, pp. 3485-3491, Seiler K et al "Electroosmotic pumping and valveless control of fluid flow within a manifold of capillaries on a glass chip" *whole document*.
Anayltical Chemistry, vol. 65, No. 10, 15 May 1993 Colombus US, pp. 1481-1488, Seiler K et al "Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency" *pg 1482, right column, para.2--p. 1848, right column, para.2; fig. 2*.
English Translation of Abstract from World Patent Index for DE-A-41 05 107 (Ciba-Geigy) (See item 1L) Oct. 1996.
Analytical Chemistry, vol. 66, No. 20, 15 Oct. 1994 Colombus US, pp. 3472-3476, Jacobson S C et al "Microchip capillary electrophoresis with an integrated postcolumn reactor" *pp. 3473, right column, para.3--pp. 3474, right column, para.1; fig. 1*.
Analytical Chemistry, vol. 66, No. 14, 15 Jul. 1994 Coloumbus US, pp. 2369-2373, Jacobson S C et al "Open channel electrochromatography on a microchip" *pp. 2371, left column, para.2--para.3; fig 1B*.
Beisner William H.
Hewlett--Packard Company
Starsiak Jr. John S.
Winfield Augustus W.
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