Synthesis of camptothecin and analogs thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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Other Related Categories

546 41, 546 48, C07D49122

Type

Patent

Status

active

Patent number

049819682

Description

ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.

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