Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1988-09-28
1991-01-01
Rivers, Diana
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
546 41, 546 48, C07D49122
Patent
active
049819682
ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
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Manikumar Govindarajan
Nicholas Allan W.
Wall Monroe E.
Wani Mansukh C.
Research Triangle Institute
Rivers Diana
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