Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-01-05
1991-01-01
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546271, C07D40112, A61K 31415
Patent
active
049818619
ABSTRACT:
Tricyclic imidazole derivatives of formula I ##STR1## wherein one of R.sup.1 and R.sup.3 is lower alkyl and the other is hydrogen or lower alkyl, R.sup.2 is lower alkyl, n is the number 0 or 1, A is ##STR2## R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each is lower alkyl land R.sup.8 is hydrogen nor lower alkyl,
and their acid addition salts are described. These compounds are useful as agents for control or prevention of ulcers and of increaased gastric acid secretion.
REFERENCES:
patent: 3623882 (1971-11-01), Gotze et al.
patent: 4435406 (1984-03-01), Krasso et al.
patent: 4554280 (1985-11-01), Krasso et al.
Fischli et al., FEBS Letters, 197, 187-191, Mar. 1986.
Fischli Albert
Krasso Anna
Ramuz Henri
Szente Andre
Coletti Ellen C.
Fan Jane T.
Gould George M.
Hoffmann-La Roche Inc.
Leon Bernard S.
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