Method and apparatus for mixing serum and reagents for chemical

Details Method and apparatus for mixing serum and reagents for chemical Method and apparatus for mixing serum and reagents for chemical

1984-09-04

1986-09-16

Sever, Frank

Chemistry: analytical and immunological testing

Including sample preparation

336127, 422224, 422225, B01F 1100, B01F 1502

Patent

active

046122915

ABSTRACT:
Method and apparatus for mixing serum and reagents for chemical analysis. The method comprises the steps of providing a container containing a serum sample and one or more reagents to be mixed, positioning an elongated mixing member within the containers and extending into the serum sample and reagents to be mixed, and then rapidly oscillating the mixing member back and forth along an arcuate path for a sufficient period of time to thoroughly mix the serum sample and reagents. The method reduces foaming of the serum sample-reagent fluid being mixed, helps to eliminate the formation of air bubbles therein and is useful as a degasser to remove air or other gases from serum-reagent mixture. Piezoelectric techniques are employed to effect the mixing with a simple and reliable apparatus. The mixing means includes a driving assembly which comprises a thin, flexible, metal plate having a pair of thin, flexible, piezoceramic elements secured to opposite faces thereof. Upon the application of an A.C. voltage across the piezoceramic elements, the elements will be caused to alternately expand and contract with one element expanding while the other element contracts, causing the free end of the assembly and the mixing blade to oscillate back and forth at a rate determined by the frequency of the applied voltage, e.g., 60 hertz, to mix the serum sample-reagent fluid.

REFERENCES:
patent: 3331589 (1967-07-01), Hammitt et al.
patent: 3780992 (1973-12-01), Nishi et al.
Document entitled, "Design Note, Piezoceramics", Piezo Electric Products, Inc., (undated).
Document entitled, "Product Specification, Piezoceramic Thin Sheet", Piezo Electric Products, Inc., (undated).
Document entitled, "Product Specification, Piezoceramic Strain Gauges", Piezo Electric Products, Inc., (undated).
Document entitled, "Product Specification, Piezoceramic Bender Elements", Piezo Electric Products, Inc., (undated).
Document entitled, "Application Note, Piezoceramic Bender Elements", Piezo Electric Products, Inc., (undated).
Document entitled, "Application Note, Soldering Procedures for Piezoceramics", Piezo Electric Products, Inc., (undated).
Document entitled, "Quadrature Fan Module B", Piezo Electric Products, Inc., (undated).
Article entitled, "Piezoelectric Devices", taken from pp. 461-463, of an unknown source.

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