Process for the preparation of taxol and 10-deacetyltaxol

Details Process for the preparation of taxol and 10-deacetyltaxol Process for the preparation of taxol and 10-deacetyltaxol

Filed on

1993-03-10

Date issued

1994-11-22

Examiner

Ivy, C. Warren

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

549511, C07D30514

Type

Patent

Status

active

Patent number

053670868

Description

ABSTRACT:
Taxol, 10-deacetyltaxol and other taxane derivatives are prepared from naturally occurring taxane-7-xylosides by the oxidative cleavage of the 7-xyloside moieties.

REFERENCES:
patent: Re32277 (1993-06-01), Denis et al.
patent: 4924011 (1990-05-01), Denis et al.
Wani, M. C., J. A. Kepler, J. B. Thompson, M. E. Wall, and S. G. Levine (1971) "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent From Taxus brevifolia" J. Am. Chem. Soc. 93:2325-2327.
Denis, Jean-Noel, and Andrew E. Greene (1988) "A Highly Efficient, Practical Approach to Natural Taxol" J. Am. Chem. Soc. 110:5917-5919.
Senilh, V., S. Blechert, M. Colin, D. Guenard, F. Picot, P. Potier, et P. Varenne (1984) "Mise En Evidence De Nouveaux Analogues Du Taxol Extraits De Taxus Baccata" Journal of Natural Products 47(1):131-137.

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