DNA encoding protein possessing metastasis-inhibitory activity

Details DNA encoding protein possessing metastasis-inhibitory activity DNA encoding protein possessing metastasis-inhibitory activity

1995-11-13

1996-12-17

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424577, 435227, 530350, 536 231, 536 232, 536 235, C07H 1900, C07H 2100, C07K 100, C07K 1400

Patent

active

055854745

ABSTRACT:
Disclosed is a novel protein which has a molecular weight of 45,000.+-.5,000 and pI 5.7.+-.0.5 and exhibits cancer metastasis-inhibitory activity. The protein can be prepared by culturing human cells, animal cells and microorganisms capable of producing the protein in a nutrient culture medium while stimulating them with an inducer such as Bacille Calmette-Gu erin and lipopolysaccharide.

REFERENCES:
patent: 5126148 (1992-06-01), Kurimoto et al.
Jakob et al, Molecular Cloning and Sequence Analysis of DNA's . . . Aminoacylase, Biological Chemistry, vol. 372, p. 684, 1991.
Cook et al, Sequence and Expression Analysis of a Chromosome . . . Cancer, J. Biol. Chem. vol. 268, pp. 17010-17017, 1993.
Y. E. Miller et al, Human Aminoacylase-1: Cloning, Regional Assignment . . . Chromosome 18, Genomics, vol. 8, pp. 149-154, 1990.
Y. Naomoto et al, Journal of Cancer Research and Clinical Oncology, vol. 113, 1987, pp. 544-549.
U. K. Laemmli, Nature, vol. 227, 1970, pp. 680-685.
J. Sambrook et al, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, 1989, Chapter 8, "Construction and Analysis of cDNA Laboratories", pp. 8.2-8.86.
Miller et al., "Human Aminoacylase-1: Cloning, Regional Assignment to Distal Chromosome 3p21.1, and identification of a Cross-Hybridizing Sequence on Chromosome 18", Genomics 8, pp. 149-154.

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