Barbituric acid antigens and antibodies specific therefor

Details Barbituric acid antigens and antibodies specific therefor Barbituric acid antigens and antibodies specific therefor

1977-12-15

1979-04-24

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 12, 260112B, G01N 3316

Patent

active

041512685

ABSTRACT:
Barbituric acid antigens are prepared by coupling 5- or 5,5-substituted barbituric acid to immunogenic carrier materials. In preferred embodiments, proteins are used as the carrier materials and the coupling is effected by an amide linkage between the 5-substituent of the barbituric acid and a carboxyl or amino group of the protein. The resulting antigens produce immunological effects when injected into host animals, including the formation of antibodies specific for 5- and 5,5-substituted barbituric acids. These specific antibodies are useful in bioanalytical techniques for the assay of barbituric acids in biological fluids.

REFERENCES:
usategui-Gomez et al., Clin. Chem., vol. 21, No. 10, Sep. 1975, pp. 1378-1382.
Spiehler et al., Clin. Chem., vol 22, No. 6, Jun. 1976, pp. 749-753.
Cleeland et al., Clin. Chem., vol. 26, No. 6, Jun. 1976, pp. 712-725.

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