Human corneal epithelial cell lines with extended lifespan

Details Human corneal epithelial cell lines with extended lifespan Human corneal epithelial cell lines with extended lifespan

1994-06-03

1996-12-17

Knode, Marian C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

43524021, 4351721, 4351723, 435948, 435 29, 4353201, C12N 500, C12N 1500, C12N 1563, C12Q 102

Patent

active

055852653

ABSTRACT:
The present invention provides human corneal epithelial cell lines with extended lifespan. The cell lines are useful as an in vitro model of the human ocular surface. Methods for making and using the cell lines are also provided.

REFERENCES:
patent: 4707448 (1987-11-01), Major
patent: 4760020 (1988-07-01), Neufeld et al.
patent: 4808532 (1989-02-01), Stampfer
patent: 4835102 (1989-05-01), Bell et al.
patent: 4885238 (1989-12-01), Reddel et al.
Rhim, J. S., Anticancer Research, 9:1345-1366 (1989).
Ueda et al., Cell Structure & Function, 16(6) p. 563 (Dec. 1991).
Kahn et al, Invest. Ophth & Vis Sci 33(4) p. 1176 (1992).
Rhim et al., Science, 227:1250-1252 (Mar. 8, 1985).
Andley et al, Invest. Ophth. & Visual Sci. 35(7) pp. 3094-3102 (Jun. 1994).
Trevithick et al, Invest. Ophth & Vis. Sci, 0(Suppl) p. 48 (1979).
Miller et al., Dev. Growth Differ, 21(1), pp. 19-28 (1979).
Robertson et al, Invest. Ophth. & Vis. Sci, 28 (3 Suppl) p. 13 (1987).
Kahn et al, Invest Ophth. & Vis. Sci 34(12) pp. 3429-3441 (Nov. 1993).
Araki et al., Invest. Ophth & Vis. Sci 34(9) pp. 2665-2671 (Aug. 1993).
Rhim et al, Leukemia, 2 (12 Suppl) pp. 151S-159S (Dec. 1988).
Kahn, et al.; Investigative Ophthalmology and Visual Science, vol. 33, No. 4, p. 1176; 1992.
Rhim; Anticancer Research, vol. 9, pp. 1345-1366, 1989.
Chaves, et al.; Investigative Ophthalmology and Visual Science, vol. 32, No. 4, p. 1072; 1991.
In Vitro Toxicity Testing, edited by J. M. Frazier, "Draize Eye Irritation Test" p. 160.
"Cultured Epithelial Cells of Cornea, Conjunctiva and Skin: Absence of Marked Intrinsic Divergence of Their Differentiated States", Tung-Tien Sun et al, Nature, vol. 269, No. 5628, pp. 489-493, Oct. 6, 1977.
"Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses", Johng S. Rhim et al, Science, Mar. 8, 1985, vol. 227, pp. 1250-1252.
"Characterization of Human Uroepithelial Cells Immortalized in Vitro by Simian Virus 40", Brian J. Christian et al, Cancer Research 47, 6066-6073, Nov. 15, 1987.
"Establishment and Characterization of SV40 T-Antigen Immortalized Human Esophageal Epithelial Cells", Stoner et al, Cancer Research, 51, 365-371, Jan. 1, 1991.
"Immortalization of Human Tracheal Gland Epithelial Cells by Adenovirus12-SV40 Hybrid Virus", Letter to the Editor by Chopra et al, In Vitro Cell Dev. Biol. 27A:763-765, Oct. 1991.
"Cloning of cDNAs for Cellular Proteins that Bind to the Retinoblastoma Gene Product", D. Defeo-Jones et al, Nature, vol. 352, Jul. 18, 1991, pp. 251-254.
"Expression of SV-40 T Antigen in the Small Intestinal Epithelium of Transgenic Mice Results in Proliferative Changes in the Crypt and Reentry of Villus-associated Enterocytes into the Cell Cycle but Has no Apparent Effect on Cellular Differentiation Programs and Does Not Cause Neoplastic Transformation", Sherrie M. Hauft et al, The Journal of Cell Biology, vol. 117, No. 4, May 1992, pp. 825-839.
"In Vitro Test Validation: A House Built on Sand", Editorial, ATLA 20, pp. 196-198, 1992.
"Malignant Human Papillomavirus Type 16-transformed Human Keratinocytes Exhibit Altered Expression of Extracellular Matrix Glycoproteins", N. Sheibani et al, Cancer Research 51, 5967-5975, Nov. 1, 1991.

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