Prolyl endopeptidase inhibitors

Details Prolyl endopeptidase inhibitors Prolyl endopeptidase inhibitors

1996-12-02

1997-08-26

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548200, 548518, A61K 31425, C07D41714

Patent

active

056611676

ABSTRACT:
The present invention relates to compounds of formula 1, ##STR1## including all of its stereoisomers, compositions, and processes for preparation of the same. The compounds of the present invention are also useful in their pharmacological activities as they directly act as inhibitors of prolyl endopeptidase and thereby provide a methods for memory enhancement, preventing or slowing the affects of amnesia or memory deficits.

REFERENCES:
patent: 4518528 (1985-05-01), Rasnick et al.
patent: 4855303 (1989-08-01), Hoover et al.
patent: 4912127 (1990-03-01), Henning
Yoshimoto, et al., Agric. Biol. Chem. 55(1), 37-43, 1991.
Saito, et al., J. Enzyme Inhibition, 1991, vol. 5, pp. 51-75.
CA Selects: Amino Acids, Peptides, & Proteins, Issue 16, 1991, 115:50303q abstracting Uchida, et al., PCT Int. Appl. WO 90 12,005 18 Oct. 1990.
CA Selects: Amino Acids, Peptides, & Proteins, Issue 9, 1991, 114: 164802m abstracting Shioiri, et al., EP Appl. 384,341, 29 Aug. 1990.
Atack, et al., European Journal of Pharmacology, 205 (1991) 157-163.
Wilk, et al., Journal of Neurochemistry, vol. 41, No. 1, 69-75, 1983.
Friedman, et al., Journal of Neurochemistry, vol. 42, No. 1, 237-241, 1984.
Nishikata, et al., Chem. Pharm. Bull. 34(7) 2931-2936 (1986).
Yoshimoto, et al., Agric. Biol. Chem., 55(1), 37-43, 1991.
CA Selects: Amino Acids, Peptides, & Proteins, Issue 24, 1991, 115:232893q abstracting Furukawa, et al., JP 03 56,460, 12 Mar. 1991.
CA Selects: Amino Acids, Peptides, & Proteins, Issue 24, 1991, 115:232874j abstracting Furukawa, et al., JP 03 56,461, 12 Mar. 1991.
Bakker, et al., Bioorganic & Medicinal Chemistry Letters, vol. 1, No. 11, pp. 585-590, 1991.
Tsuru, et al., J. Biochem. 104, 580-586 (1988). J. Burkhart to KJC Mar. 20, 1992.
Yoshimoto, et al., Biochemistry, vol. 16, No. 13, pp. 2942-2948, 1977.
Angelastro, et al., Tetrahedron Letters, vol. 33, No. 23, pp. 3265-3268, 1992.
Sham, H.L. et al., FEBS Letters, vol. 220, No. 2, pp. 299-301 (1989).
Powers, J.C., Eleventh American Peptide Symposium, Abstracts, The Salk Institute and University of CA, San Diego (1989).
Imperiali, B., et al., Biochemistry, vol. 25, 3760-3767 (1986).
Stein, R.L., et al., Biochemistry 26, 2682-2689 (1987).
Chemical Abstracts 110:76058k, vol. 110 (1989), abstracting Angliker, H., et al., Biochem. J. 256(2), 481-6, 1988.
Chemical Abstracts 106:850589f, vol.106 (1987), abstracting JP 86, 183,253, Aug. 15, 1986.
Ueda, T. et al., Biochem. J. 265, 539-545 (1990).
Synthesis, 676-678 (1983). Internal report.
Gassman, P.G., et al., J. Org. Chem. 52, 2481-2490 (1987). Internal report.
Tsuru, et al., J. Biochem., 104, 580-586 (1988).

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