Production of optical isomers of certain 1,6-naphthyridine-3-car

Details Production of optical isomers of certain 1,6-naphthyridine-3-car Production of optical isomers of certain 1,6-naphthyridine-3-car

1990-02-27

1991-08-06

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47104

Patent

active

050379879

ABSTRACT:
The present invention provides a process for the separation of the naphthyridine derivatives (.+-.)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-n aphthyridine-3-carboxylic acid ethyl ester and (.+-.)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-n aphthyridine-3-carboxylic acid [2-(N-methyl-N-phenylmethylamino)ethyl] ester into the optical antipodes by use of the (.+-.)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-n aphthyridine-3-carboxylic acid benzyl ester and optically-active O,O'-dibenzoyltartaric acid. Said optical antipodes are calcium antagonists useful in the treatment of blood vessel diseases.

REFERENCES:
patent: 3832388 (1984-08-01), Lorenz
patent: 4711901 (1987-12-01), Satzinger et al.
patent: 4751228 (1988-06-01), Kleinschroth et al.
patent: 4760081 (1988-07-01), Satzinger et al.

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