Immortalized human cell lines containing exogenous cytochrome P4

Details Immortalized human cell lines containing exogenous cytochrome P4 Immortalized human cell lines containing exogenous cytochrome P4

1995-06-05

1997-08-26

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4351721, 435 29, 435 32, C12Q 168

Patent

active

056609868

ABSTRACT:
Non-tumorigenic, stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, chemotherapeutic and chemo-preventive agents utilizing these cell lines.

REFERENCES:
patent: 4675002 (1987-06-01), Viles et al.
patent: 5356806 (1994-10-01), Harris et al.
Bayad et al., Biochem. Pharmacol., vol. 42, 1991, pp. 1345-1351.
Nebert et al., DNA and Cell Biology, vol. 10, 1991, pp. 1-14.

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