Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1990-04-17
1991-08-06
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514313, 514318, 549214, 549222, 549213, 549318, A61K 31665, A61K 3147, C07D30512, C07D 906
Patent
active
050378112
ABSTRACT:
Compounds of the formula ##STR1## in which R.sub.1 is H or alkyl of 1 to 20 carbons, CO--R.sub.1.sup.* CO--O--R.sub.1.sup.* CO--NH--R.sub.1.sup.* or PO(OR.sub.1.sup.*).sub.2 or PO(OR.sub.1.sup.*)R.sub.1.sup.* where R.sub.1.sup.* independently is H, alkyl of 1 to 20 carbons, phenyl, or substituted phenyl; X is O, S, SO--, SO.sub.2, NH--, or NR.sub.2 where R.sub.2 is phenyl, substituted phenyl or alkyl of 1 to 20 carbons, and Y is alkyl having at least 6 carbon atoms, arylalkyl, aryl, substituted aryl, substituted arylalkyl, alkenyl containing one or more olephinic bonds and at least 6 carbon atoms, CO--R.sub.3, CO--OR.sub.3, CONHR.sub.3, SO.sub.2 R.sub.3, SO.sub.2 NHR.sub.3 where R.sub.3 is aryl, substituted aryl, substituted arylalkyl, alkyl, alkenyl containing one or more olephinic bonds, further Y is (CH.sub.2).sub.n --O--R.sub.4, or (CH.sub.2).sub.n --O--(CH.sub.2).sub.m --O--R.sub.4, where n, and m, are integers and are independently 1 to 25 and R.sub.4 is phenyl, substituted phenyl or alkyl of one to 20 carbons, still further Y is PO(OH).sub.2, PO(OH)OR.sub.5, PO(OH)R.sub.5 PO(OR.sub.5).sub.2, where R.sub.5 is independently phenyl, substituted phenyl, alkyl or 1 to 20 carbons or R.sub.5 is (CH.sub.2).sub.n --N(R.sub.5.sup.*).sub.3 where R.sub.5.sup.* is alkyl of 1 to 20 carbons, or Y is NH--R.sub.6 where R.sub.6 is phenyl, substituted phenyl or alkyl of at least 6 carbon atoms with the proviso that when X is O, S, then Y is not NH--R.sub.6, and with the further proviso that when X is SO or SO.sub.2 then Y is not SO.sub.2 R.sub.3 or SO.sub.2 NHR.sub.3, are disclosed. The compounds possess anti-inflammatory activity.
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Allergan Inc.
Baran Robert J.
Shen Cecilia
Szekeres Gabor L.
Voet Martin A.
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