Methods of contraception

Details Methods of contraception Methods of contraception

1989-03-20

1991-08-06

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530395, 424 858, A61K 3743, C07K 1300

Patent

active

050378058

ABSTRACT:
Methods are disclosed for regulating ovulation or fertility in female mammals, for regulating spermatogenesis in males and for treating conditions such as endometriosis. Administration of effective amounts of an FSH-Inhibiting Protein (FSH-IP) can be used for female contraception and also for male contraception by preventing sperm production. FSH-IP, in its native form, is a glycosylated protein having an apparent molecular weight of about 50,000 Daltons (50kD) which inhibits the production of estradiol that would otherwise be stimulated by FSH in certain cells, such as granulosa cells. Antibodies to these FSH-IP proteins, preferably of monoclonal form can be produced using techniques presently known in the art and are useful for treatment to promote ovulation or superovulation in mammals, including humans and livestock.

REFERENCES:
patent: 4734398 (1988-03-01), DiZerega
patent: 4764502 (1988-08-01), DiZerega
DiZerega et al., "Identification of Protein(s) Secreted by the Preovulatory Ovary which Suppresses the Folicle Response to Gonadotropins," J. Clin. Endocrinol. & Metabolism, 56(1): 1091-1096 (1983).
DiZerega et al., "Activity of a Human Follicular Fluid Protein(s) in Spontaneous and Induced Ovarian Cycles," J. Clin. Endocrinol. & Metabolism, 57(4): 838-846 (1983).
DiZerega et al., "Identification of Proteins in Pooled Human Follicular Fluid which Suppress Follicular Response to Gondadotropins," J. Clin. Endocrinol. & Metabolism, 54(6): 35-41 (1983).
DiZerega et al., "Human Granulosa Cell Secretion of Protein(s) which Suppress Follicular Response to Gonadotropins," J. Clin. Endocrinol. & Metabolism, 56(1): 147-155 (1983).
Kling et al., "Identification of a Porcine Follicular Fluid Fraction which Suppresses Follicular Response to Gonadotropins," Biology of Reproduction, 30: 564-472 (1984).
Ono et al., "Biochemical and physiologic characterization of follicle regulatory protein: A paracrine regulator of folliculogenesis," Am. J. Obstet. Gynecol., 709-716, Apr. (1986).
Wood et al., "Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein," Molecular Endocrinology, 2(12): 1176-1185 (1988).
Baxter et al., "Binding Proteins for Insulin-Like Growth Factors in Adult Rat Serum.," Biochem. & Biophyl. Res. Comm., 147(1): 408-415, Aug. 31, 1987.

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