Crystallization process for cefazolin sodium

Details Crystallization process for cefazolin sodium Crystallization process for cefazolin sodium

1977-06-03

1978-08-01

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50136

Patent

active

041044703

ABSTRACT:
The cephalosporin antibiotic, cefazolin sodium, is provided in the monohydrate crystalline form substantially free of other crystalline forms via addition of a concentrated solution of cefazolin acid in a water-miscible organic solvent such as DMAC to a sodium cation donor solution, e.g., sodium acetate in ethanol, wherein said sodium cation donor solution contains water in an amount sufficient to constitute 3-7 percent by volume of the mixed solutions.

REFERENCES:
patent: 3516997 (1970-06-01), Takano et al.
Kariyone et al., The Jour. of Antibiotics, vol. XXIII [3], pp. 131-135, (Mar. 1970).

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