Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalo

Details Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalo Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalo

1977-06-10

1978-08-01

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

542420, C07D40512

Patent

active

041043855

ABSTRACT:
Compounds useful as schistosomicidal agents are cyclic alkylidenyl N-[6-(R.sub.3 R.sub.4 N)-4(or 5)-R.sub.5 -3-pyridazinyl]aminomethylenemalonates (I), where R.sub.3 R.sub.4 N is lower-tertiary-amino and R.sub.5 is hydrogen or lower-alkyl, are prepared by reacting 3-amino-6-(R.sub.3 R.sub.4 N)-4(or 5)-R.sub.5 -pyridazine (III) with cyclic alkylidenyl .alpha.-(lower-alkoxymethylene)malonate (IV) or by heating equimolar quantities of III, tri-(lower-alkyl) orthoformate and cyclic alkylidenyl malonate (V). Also shown is cyclic isopropylidenyl N-(6-methylamino-3-pyridazinyl)aminomethylenemalonate, a schistosomicidal agent, and its preparation. Also shown are schistosomicidal compositions comprising as active component a schistosomicidally effective cyclic alkylidenyl N-[6-(R.sub.3 R.sub.4 N)-4(or 5)-R.sub.5 -3-pyridazinyl]aminomethylenemalonate (I) or cyclic isopropylidenyl N-(6-methylamino-3-pyridazinyl)aminomethylenemalonate (II) or salt thereof and a method for the treatment of schistosomiasis which comprises administering to a host infected with schistosomes a schistosomicidally effective amount of said active component.

REFERENCES:
patent: 3563981 (1971-02-01), Lesher

Affiliated with

Also associated with

Rating

Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1979861