Thiophene-2-carboxamidotetrazoles and pharmaceutical use thereof

Details Thiophene-2-carboxamidotetrazoles and pharmaceutical use thereof Thiophene-2-carboxamidotetrazoles and pharmaceutical use thereof

1994-08-09

1995-11-07

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 546114, 548252, C07D40312, C07D49504, A61K 3144, A61K 3141

Patent

active

054648556

ABSTRACT:
Thiophene-2-carboxamidotetrazoles inhibit the Mac-1 integrin and are thus useful for treating diseases mediated by Mac-1 adhesion, including inflammatory disorders.

REFERENCES:
The Journal of Immunology, vol. 144, No. 7, Apr. 1990; Shappell et al., pp. 2702-2711.
Journal of Leukocyte Biology, vol. 48, 1990, Rosen, pp. 465-469.
The Journal of Immunology, vol. 150, No. 6, Mar. 1993, Mulligan et al., pp. 2401-2406.
Circulation, vol. 81, No. 1, Jan. 1990, Simpson et al., pp. 226-237.
Gastroenterology, vol. 100, No. 4, 1991, Wallace et al., pp. 878-883.
American Journal of Physiology, vol. 259, 1990, Wallace et al., pp. G462-G467.

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