N-(acylaminomethyl)glutaryl amino acids and use

Details N-(acylaminomethyl)glutaryl amino acids and use N-(acylaminomethyl)glutaryl amino acids and use

1992-09-23

1993-05-04

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514482, 514483, 514562, 514563, 544169, 560 13, 560 25, 560 27, 562430, 562439, A61K 31195, A61K 31535, C07C27516, C07D29515

Patent

active

052082369

ABSTRACT:
Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino;

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Erdos, Hypertension, 16, 4 (1990) pp. 363-370.
Zimmerman, et al., Cir. Res., 66, 1 (1990), pp. 234-240.
Sybertz, et al., J. Pharmacol. Exp. Thes., 250, 2 (1989), pp. 624-631.
Sybertz, et al., Hypertension, 15, 2 (1990), pp. 152-161.
Johnston et al., Am. J. Med., 87, (Suppl. 6) (1989), pp. 245-285.
Gros, et al., Proc. Nat. Acad. Sci., 88, (1991), pp. 4210-4214.

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