NMDA antagonists

Details NMDA antagonists NMDA antagonists

1995-06-05

1997-02-25

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546162, C07D21506

Patent

active

056060637

ABSTRACT:
The present invention is directed to a new class of 4-sulfanimide-quinoline derivatives and to their use as NMDA antagonists.

REFERENCES:
patent: 5026700 (1991-06-01), Harrison et al.
Wright, Synthens, 1984, Dec. pp. 1058-1061.
Journal of Medicinal Chemistry, vol. 33, No. 12, 1990, B. L. Harrison et al.: "4-[(Carboxymethyl)oxyl]-and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-c arboxylic acid: New antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate receptor complex".

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