Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1994-05-24
1997-02-25
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 852, 435 6952, C07K 14525, A61K 3819, C12N 1528
Patent
active
056060238
ABSTRACT:
Mutant tumor necrosis factor proteins which retain full or near full capability to bind to a TNFR-p75 receptor while retaining only a limited capability to bind a TNFR-p55 receptor are provided. Methods of inhibiting toxicity induced by tumor necrosis factor by treating cells or tissues having a tumor necrosis factor receptor with these mutant human tumor necrosis factor proteins are also provided. Pharmaceutical compositions and methods of inhibiting systemic tumor necrosis factor induced toxicity in a patient undergoing antitumor TNF-.alpha. therapy with these compositions are also provided.
REFERENCES:
Gennaro, Alfonso, Ed., Remington's Pharmaceutical Sciences, 18th Edition, Mack Publishing Co., Easton, PA, 1990.
Goodwin et al., "Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor", Mol. Cell Biol. 1991, 11:3020-3026.
Gray et al., "Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein", Proc. Natl. Acad. Sci. USA 1990, 87:7380-7384.
Kunkel T. A., "Rapid and efficient site-specific mutagenesis without phenotypic selection", Proc. Nat'l. Sci. USA 1985 82:488-492.
Kunkel T. A. et al., "Rapid and efficient site-specific mutagenesis without phenotypic selection", Methods in Enzymol., 154:367-382.
Loetscher et al., "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor", Cell 1990, 61:351-359.
Loetscher et al., "Human Tumor Necrosis Factor .alpha.(TNF.alpha.) Mutants with Exclusive Specificity for the 55-kDA or 75-kDA TNF Receptors", J. Biol. Chem., 1993, 268(35):26350-26358.
Schall et al., "Molecular cloning and expression of a receptor for tumor necrosis factor", Cell 1990, 61:361-370.
Shortle D. et al., "Local mutagenesis: A method for generating viral mutants with base substitutions in preselected regions of the viral genome", Proc. Nat'l, Sci. USA 1978, 75:2170-2174.
Smith et al., "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins", Science 1990, 248:1019-1023.
Van Ostade et al., "Human TNF mutants with selective activity on the p55 receptor", Nature 1993, 361:266-268.
Zhang et al., "Site-directed Mutational Analysis of Human Tumor Necrosis Factor-.alpha. Receptor Binding Site and Structure-Functional Relationship", J. Biol. Chem. 1992, 267(33):24069-24075.
Schulz & Schirmer, published 1979, by Springer-Verlag New York, Inc., pp. 14-16.
Barbara et al. (1994), The EMBO Journal, vol. 13, pp. 843-850.
Varr Ostade et al. (1994) Eur. J. Biochem, vol. 220, pp. 771-779.
Bouie et al. (1990), Science vol. 247 pp. 1306-1310.
Chen Mann-Jy
Weber Irene T.
Mertz Prema
Thomas Jefferson University
Ulm John
LandOfFree
Mutant tumor necrosis factor proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutant tumor necrosis factor proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant tumor necrosis factor proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1974856