Method of treating dysmenorrhea employing an interphenylene 7-ox

Details Method of treating dysmenorrhea employing an interphenylene 7-ox Method of treating dysmenorrhea employing an interphenylene 7-ox

Filed on

1994-12-22

Date issued

1997-02-25

Examiner

Rollins, John W.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

514212, 514325, 514328, 514374, 514381, 514899, A61K 3141, A61K 3155, A61K 31445, A61K 3142

Type

Patent

Status

active

Patent number

056059175

Description

ABSTRACT:
A method is provided for treating dysmenorrhea (menstrual cramps) employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog thromboxane A.sub.2 receptor antagonist such as ifetroban, alone or in combination with a non-steroidal anti-inflammatory drug (NSAID).

REFERENCES:
patent: 5100889 (1992-03-01), Misra et al.
F. Bertolino, et al., "Intrinsic Activity of the Non-Prostanoid Thromboxane A2 Receptor Antagonist, Daltroban (BM 13,505), in Human Platelets invitro and in the Rat Vasculature invivo", Br. J. Pharm. 115:210-216 1995.
I. Miki, et al., "Differences in Activities of Thromboxane A2 Receptor Antagonists in Smoteh Muscle Cells", Eup. J. Pharm.-Mol. Pharm. Sect. 227:199-204 1992.
G. P. Dube, et al., "I Vivo Effects of a Novel Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Partial Agonist, (+)5(Z)-7[3-endo-phenylsulfonylamino[2.2.1]-bicyclohept-2-exo-yl]-heptenoi c acid [(+)-S-145], Vascular, Platelet and Cardiac Function". 272(2):799-1995.
M. L. Ogletree, et al., "Pharmacological Profile of BMS180,291:A Potent, Long-Acting, Orally Active Thromboxane A2/Prostaglandin Endoperoxide Receptor Antagonist", The J. Pharm and Espt. Ther. 264(2):570-578 1993.

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