Process for the preparation of indole compounds from N-protected

Details Process for the preparation of indole compounds from N-protected Process for the preparation of indole compounds from N-protected

1995-10-26

1996-11-26

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20910

Patent

active

055787355

ABSTRACT:
The present invention relates to a novel process for the preparation of indole compounds of the formula II: ##STR1## from N-protected indolines of the formula I. ##STR2##

REFERENCES:
Kiguchi, et al. "One-Pot Synthesis of Indoles from 1-Benzyl-2,3-dihydroindoles" Syntheisis, 1989, pp. 778-781.
Bajwa, "One-Pot Transformation of Benzyl Carbamates into t-Butyl Carbamates", Terahedron Letters, vol. 33, No. 21, 1992, pp. 2955-2956.
Felix, et al. "Rapid Removal of Protecting Groups from Peptides by Catalytic Transfer Hydrogenation with 1,4-Cyclohexadiene" J. Org. Chem., vol. 43, No. 21, 1978.
Kametani et al., Studies on the Syntheses of Heterocyclic Compounds. Part 865..sup.1 A Novel Synthesis of Indole Derivatives by Intramolecular Nucleophilic Aromatic Substitution, J. C. S. Perkin 1, 1981, pp. 290-294.
Jackson, "Rapid Selective Removal of Benzyloxycarbonyl Groups from Peptides by Catalytic Transfer Hydrogenation", Synthesis, 1976, pp. 685-687.

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