Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-01-19
1997-02-25
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 4351723, 4352523, 4353201, 536 231, 536 235, 536 2431, 935 11, 935 22, 935 66, C07K 1452, C12N 1519
Patent
active
056058179
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode FSEC, expression vectors for the production of purified FSEC, antibodies capable of binding specifically to FSEC, hybridization probes or oligonucleotides for the detection of FSEC-encoding nucleotide sequences, genetically engineered host cells for the expression of FSEC, diagnostic tests for chemokine activation based on FSEC-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
REFERENCES:
Jan Vilcek, et al., Immunology of Cytokines, The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 1, pp. 1-17.
Alan R. Shaw, Molecular Biology of Cytokines, The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 2, pp. 20-46.
Jacques Banchereau, Interleukin-4, The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 6, pp. 120-148.
Thomas J. Schall, The Chemokines, The Cytokine Handbook, Academic Press, 1994, Sep. 19-20, 1994, Second Edition, pp. 180-272.
Sudo et al. (1994) Genomics 24:276-279.
Baixevas et al. (1990) Mol. Immunol. 27:1091-1102.
Brown et al (1989), J. of Immunol. 142:679-687.
Charu et al (1986) J. Biochem. 99:885-894.
Zipfel et al (1989) J. Immunol. 142:1582-1590.
Coleman Roger
Seilhamer Jeffrey J.
Wilde Craig G.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
Mertz Prema
Ulm John
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