Pyropheophorbides conjugates and their use in photodynamic thera

Details Pyropheophorbides conjugates and their use in photodynamic thera Pyropheophorbides conjugates and their use in photodynamic thera

1992-11-09

1994-05-24

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 2, 5303911, 5303913, 5303915, 5303917, 5303919, 540145, A61K 3140, C07D48722

Patent

active

053149050

ABSTRACT:
Conjugate are formed by covalently linking a target-specific compound to pyropheophorbide compound which conjugated are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compound component of the conjugate is exposed to a particular wavelength of light the compound becomes cytotoxic destroying the tumor or diseased tissue without causing irreversible normal tissue damage. The pyropheophorbide compounds have been shown to have a variety of characteristics when used in photodynamic therapy. These characteristics are further improved when the compounds are bound to a target specific component such as a ligand capable of binding to a specific cellular receptor (e.g. growth hormones and growth factors) or an antibody capable of binding to a particular antigen.

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