Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-01-12
1996-11-26
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 721, 435975, G01N 3353, G01N 33567
Patent
active
055784518
ABSTRACT:
A method of identifying a therapeutic useful for treating or preventing Alzheimer's disease, which method includes the steps of contacting (a) a first molecule containing the couplone portion of APP (SEQ ID NO: 1) with (b) a second molecule containing the amino acid sequence of G.sub.o (SEQ ID NO: 2) or an APP-associating region of G.sub.o (SEQ ID NOs: 3, 4, or 5), in the presence of a candidate compound; and determining whether the candidate compound interferes with the association of the first and second molecules, such interference being an indication that the candidate compound is a potential Alzheimer's disease therapeutic.
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Duffy Patricia A.
Knode Marian C.
The General Hospital Corporation
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