Method and composition for treating IgE-mediated allergies

Drug – bio-affecting and body treating compositions – Lymphokine

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424 91, 424114, 514 15, 514885, A61K 3724, A61K 3935, A61K 3936

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active

053146905

ABSTRACT:
The present invention relates to a method and preparations for reducing IgE antibodies to allergens in allergic subjects wherein substance P and an allergen or fragments of allergens or haptens acting as allergens are administered together to the allergic subjects. The method can be used to treat humans and animals including dogs, cats, horses and subhuman primates.

REFERENCES:
patent: 4740371 (1988-04-01), St. Remy et al.
patent: 4946945 (1990-08-01), Wojdani
Anderson, et al. "Preseasonal Polymerized Ragweed Immunotherapy in Canine Allergic Inhalant Dermatitis (AID)-A Pilot Study," J. Allergy Clin. Immunol. 69:116, (1982) (Part 2).
Bienenstock, et al. "Neuroendocrine Regulation of Mucosal Immunity" Immunol. Invest. 18:69-76 (1989).
Chang, et al. "Amino-acid Sequence of Substance P" Nature New Biology 232:86-87 (1971).
Cook, et al. "Serological Evidence of Immunity With Coexisting Sensitization in a Type of Human Allergy (Hay Fever)" J. Experimental Medicine 62:744-750 (1935).
Euler, et al. "An Unidentified Depressor Substance in Certain Tissue Extracts" J. Physiology 72:74-87 (1931).
Fuller, et al. "Effect of Substance P on Cardiovascular and Respiratory Function in Subjects" American Physio. Soc. pp. 1473-1479 (1987).
Ghory, et al. "In vitro IgE Formation by Peripheral Blood Lymphocytes From Normal Individuals and Patients With Allergic Bronchopulmonary Aspergillosis" Clin. Exp. Immunol. 40:581-585 (1980).
Goetzl, et al. "Neuropeptides, Mast Cells and Allergy: Novel Mechanisms and Therapeutic Possibilities" Clin. Experimental Allergy 20, Supplement 4:3-7 (1990).
Machiels, et al. "Allergic Bronchial Asthma Due to Dermatophagoides pteronyssinus Hypersensitivity Can Be Efficiently Treated by Inoculation of Allergen-Antibody Complexes" J. Clin. Invest. 85:1024-1035 (1990).
Macy, et al. "Enhanced ELISA: How to Measure Less Than 10 Picograms of a Specific Protein (Immunoglobulin) in Less Than 8 Hours" FASEB J. 2:3003-3009 (1988).
Melam, et al. "Correlations Between Clinical Symptoms, Leukocyte Sensitivity, Antigen-Binding Capacity, and Prausnitz-Kustner Activity in a Longitudinal Study of Ragweed Pollinosis" J. Allerg. 46:292-299 (1970).
McGillis, et al. "Substance P and Immunoregulation" Fed. Proceed. 46:196-199 (1987).
O'Dorisio, et al. "Vasoactive Intestinal Piptide and Neuropeptide Modulation of the Immune Response" J. Immunol. 135:792-796 (1985).
Patterson, et al. I "Aerosolized Antigen Dose-response Studies in Asthmatic Monkeys" J. Lab. Clin. Med. 92:283-289 (1978).
Patterson, et al. II "Animal Models of the Asthmatic State" Annual Rev. of Med. 25:53-68 (1974).
Patterson, et al. III "Effects of Combined Receptor Antagonists of Leukotriene D.sub.4 (LTD.sub.4) and Platelet-Activating Factor (PAF) on Rhesus Airway Responses to LTD.sub.4, PAF and Antigen" Int. Arch. Allergy Appl. Immunol. 88:462-470 (1989).
Patterson, et al. IV "Induction of IgE-mediated Cutaneous, Cellular, and Airway Reactivity in Rhesus Monkeys by Ascaris suum Infection" J. Lab. Clin. Med. 101:864-872 (1983).
Patterson, et al. V "In Vitro Production of IgE by Human Peripheral Blood Lymphocytes: Effect of Cholera Toxin and .beta. Adrenergic Stimulation" J. Immunol. 117:97-101 (1976).
Patterson, et al. VI "In vitro production of IgE by Lymphocytes From a Patient With Hyperimmunoglobulinaemia E, Eosinophilia and Increased Lymphocytes Carrying Surface IgE" Clin. Exp. Immunol. 20:265-272 (1975).
Patterson, et al. VII "Living Histamine-Containing Cells From the Bronchial Lumens of Humans" J. Clin. Invest. 59:217-225 (1977).
Patterson, et al. VIII "Parallel Induction of IgE-mediated Ascaris Antigen Airway Responses and Increased Carbachol Airway Reactivity in Rhesus Monkeys by Infection With Ascaris suum" J. Clin. Lab. Med. 106:293-297 (1985).
Patterson, et al. IX "Reagin-mediated Asthma in Rhesus Monkeys and Relation to Bronchial Cell Histamine Release and Airway Reactivity to Carbocholine" J. Clin. Invest. 57:586-593 (1976).
Patterson, et al. X "Respiratory Responses in Subhuman Primates With Immediate Type Hypersensitivity" J. Lab. Clin. Med. 73:924-933 (1969).
Patterson, et al. XI "Rhesus Monkey Responses to Substance P" Int. Arch. Allergy Immunol. 91:374-379 (1990).
Patterson, et al. XII "Studies of Platelet Activating Factor in Primates" New Horizons in Platelet Activating Factor Research, pp. 311-316 (1987).
Payan, et al. "Binding Characteristics and Affinity Labeling of Protein Constituents of the Human IM-9 Lymphoblast Receptor for Substance P" J. Biol. Chem. 261:14321-14329 (1986).
Payan, et al. "Substance P Recognition by a Subset of Human T Lymphocytes" Amer. Soc. Clin. Invest., Inc. 74:1532-1539 (1984).
Siemion, et al. "Immunoregulatory Activity of Substance P Fragments" Molecular Immunol. 27:887-890 (1990).
Stanworth, et al. "Allergy Treatment With a Peptide Vaccine" Lancet 336:1279-1281 (1990).

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